Effect of Silica-Alumina Adsorbent on the Efficiency of Paclitaxel Purification 


Vol. 19,  No. 3, pp. 342-346, Sep.  2013
10.7464/ksct.2013.19.3.342


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  Abstract

Several types of mesoporous silica-alumina adsorbents with varied SiO2/Al2O3 ratios were prepared by spray pyrolysis and were used for the purification of the anticancer agent paclitaxel. When S0.5A0.5 (Silica/Alumina molar ratio = 0.5/0.5) was used, the highest purity (~27%) and yield (~63%) of paclitaxel were obtained from adsorbent treatment and hexane precipitation. Removal of impurities was confirmed by TGA analysis of the organic substances that were adsorbed to the adsorbent.

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  Cite this article

[IEEE Style]

O. HJ, J. KY, K. JH, "Effect of Silica-Alumina Adsorbent on the Efficiency of Paclitaxel Purification," Clean Technology, vol. 19, no. 3, pp. 342-346, 2013. DOI: 10.7464/ksct.2013.19.3.342.

[ACM Style]

Oh HJ, Jung KY, and Kim JH. 2013. Effect of Silica-Alumina Adsorbent on the Efficiency of Paclitaxel Purification. Clean Technology, 19, 3, (2013), 342-346. DOI: 10.7464/ksct.2013.19.3.342.

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한국연구재단 등재학술지