Preparation of Micro- and Submicron-Particles of a Poorly Water-Soluble Antifungal Drug Using Supercritical Fluid Process 


Vol. 16,  No. 2, pp. 80-87, Jun.  2010


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  Abstract

In this study, micro- and submicron particles of itraconazole, a poorly water-soluble antifungal drug, were prepared for improving its aqueous solubility using an ultrasound-assisted supercritical fluid technique, called SAS-EM. The SAS-EM process used in our experiments was different from the conventional SAS-EM in that the ultrasound was applied directly to the spray nozzle. The effect of the ultrasonic power, temperature, and solvent on the formation of itraconazole particles were investigated. Smaller particles were obtained through our SAS-EM process compared with the ASES process, and the mean particle size decreased as the ultrasonic power increased. Our experimental results confirmed that the ultrasound-assisted supercritical fluid process is an efficient method for producing ultrafine particles.

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  Cite this article

[IEEE Style]

K. SY, L. JM, W. BH, J. II, R. JH, L. GB, "Preparation of Micro- and Submicron-Particles of a Poorly Water-Soluble Antifungal Drug Using Supercritical Fluid Process," Clean Technology, vol. 16, no. 2, pp. 80-87, 2010. DOI: .

[ACM Style]

Kim SY, Lee JM, Won BH, Jung II, Ryu JH, and Lim GB. 2010. Preparation of Micro- and Submicron-Particles of a Poorly Water-Soluble Antifungal Drug Using Supercritical Fluid Process. Clean Technology, 16, 2, (2010), 80-87. DOI: .

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pISSN : 1598 - 9712
eISSN : 2288 - 0690

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