Green Synthesis of MIL-100(Fe) as Porous Drug Carrier for Controlled Release of Indomethacin 


Vol. 31,  No. 3, pp. 199-206, Sep.  2025
10.7464/ksct.2025.31.3.199


PDF
  Abstract

Developing a controllable drug delivery system is critical for reducing side effects and improving drug therapeutic efficacy. The utilization of metal-organic-frameworks (MOFs) in the drug delivery field has attracted immense attention over the past few years due to their unique structural and chemical features. In this study, the potential role of MIL-100(Fe) (MIL stands for Material Institute Lavoisier) as a drug carrier was confirmed through controlled release studies. Using an eco-friendly approach, the synthesized MIL-100(Fe) aided in loading indomethacin (IND) and then the controlled release effects were examined. The estimated drug loading capacity was around 9.6% and was confirmed by ultra-violet visible (UV-vis) spectroscopy and thermogravimetric analysis (TGA). Moreover, the physico-chemical properties of MIL-100(Fe) and MIL-100(Fe)-IND were confirmed and supported by various analysis techniques. Furthermore, the release profile of IND was investigated under two different pH conditions. The obtained release profiles showed diffusion-controlled release indicating that a MIL-100(Fe) MOF could be used as a potential drug carrier.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

U. T. Uthappa, S. H. An, H. Jeong, "Green Synthesis of MIL-100(Fe) as Porous Drug Carrier for Controlled Release of Indomethacin," Clean Technology, vol. 31, no. 3, pp. 199-206, 2025. DOI: 10.7464/ksct.2025.31.3.199.

[ACM Style]

Uluvangda Thammaiah Uthappa, Seung Hui An, and Heon-Ho Jeong. 2025. Green Synthesis of MIL-100(Fe) as Porous Drug Carrier for Controlled Release of Indomethacin. Clean Technology, 31, 3, (2025), 199-206. DOI: 10.7464/ksct.2025.31.3.199.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

pISSN : 1598 - 9712
eISSN : 2288 - 0690

한국연구재단 등재학술지