Solubility of Ibuprofen in Supercritical Carbon Dioxide 


Vol. 11,  No. 3, pp. 147-152, Sep.  2005


PDF
  Abstract

For estblishing the best technique for the micronization of Ibuprofen using supercritical fluids, the solubility should be known. The solubility of Ibuprofen in supercritical carbon dioxide was measured by observing the cloud point. The cloud point was observed using high pressure equipment equipped a variable volume view cell between temperature of 35, 40 and 45 °C. The solubility data was sorrelated by the Peng-Robinson equation of state Solute physical properties, such as critical temperature (Tc), critical pressure (Pc) and acentric factor (ω) were estimated by the some group contribution method. As pressure was increased, the solubility increased at constant temperature. The retrograde phenomenon by a solute vapor pressure and a density of solvent was obwerved at the pressure of around 150bar. It was found that CO2 can be used as a supercritical solvent in micronization of iburofen by RESS.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

K. YA, C. J, L. JS, K. H, L. YW, "Solubility of Ibuprofen in Supercritical Carbon Dioxide," Clean Technology, vol. 11, no. 3, pp. 147-152, 2005. DOI: .

[ACM Style]

Kim YA, Chu J, Lim JS, Kim H, and Lee YW. 2005. Solubility of Ibuprofen in Supercritical Carbon Dioxide. Clean Technology, 11, 3, (2005), 147-152. DOI: .

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

pISSN : 1598 - 9712
eISSN : 2288 - 0690

한국연구재단 등재학술지